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Protons and Psalmotoxin-1 reveal nonproton ligand stimulatory sites in chicken acid-sensing ion channel: Implication for simultaneous modulation in ASICs

Acid-sensing ion channels (ASICs) are proton-sensitive, sodium-selective channels expressed in the nervous system that sense changes in extracellular pH. These ion channels are sensitive to an increasing number of nonproton ligands that include natural venom peptides and guanidine compounds. In the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Smith, Rachel N, Gonzales, Eric B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048342/
https://ncbi.nlm.nih.gov/pubmed/24262969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.26978
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