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Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channels
Acid-sensing ion channels (ASICs) are known to be primarily activated by extracellular protons. Recently, we characterized a novel nonproton ligand (2-guanidine-4-methylquinazoline, GMQ), which activates the ASIC3 channel subtype at neutral pH. Using an interactive computational-experimental approac...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137073/ https://ncbi.nlm.nih.gov/pubmed/21586569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.239558 |
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