Caricamento...

Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channels

Acid-sensing ion channels (ASICs) are known to be primarily activated by extracellular protons. Recently, we characterized a novel nonproton ligand (2-guanidine-4-methylquinazoline, GMQ), which activates the ASIC3 channel subtype at neutral pH. Using an interactive computational-experimental approac...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Yu, Ye, Li, Wei-Guang, Chen, Zhi, Cao, Hui, Yang, Huaiyu, Jiang, Hualiang, Xu, Tian-Le
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137073/
https://ncbi.nlm.nih.gov/pubmed/21586569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.239558
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !