Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channels

Acid-sensing ion channels (ASICs) are known to be primarily activated by extracellular protons. Recently, we characterized a novel nonproton ligand (2-guanidine-4-methylquinazoline, GMQ), which activates the ASIC3 channel subtype at neutral pH. Using an interactive computational-experimental approac...

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Main Authors: Yu, Ye, Li, Wei-Guang, Chen, Zhi, Cao, Hui, Yang, Huaiyu, Jiang, Hualiang, Xu, Tian-Le
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Molecular Biophysics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137073/
https://ncbi.nlm.nih.gov/pubmed/21586569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.239558
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