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Protons and Psalmotoxin-1 reveal nonproton ligand stimulatory sites in chicken acid-sensing ion channel: Implication for simultaneous modulation in ASICs

Acid-sensing ion channels (ASICs) are proton-sensitive, sodium-selective channels expressed in the nervous system that sense changes in extracellular pH. These ion channels are sensitive to an increasing number of nonproton ligands that include natural venom peptides and guanidine compounds. In the...

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Autors principals: Smith, Rachel N, Gonzales, Eric B
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048342/
https://ncbi.nlm.nih.gov/pubmed/24262969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.26978
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