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In vivo Targeting of Adoptively Transferred T-cells with Antibody- and Cytokine-Conjugated Liposomes

In adoptive cell therapy (ACT), autologous tumor-specific T-cells isolated from cancer patients are activated and expanded ex vivo, then infused back into the individual to eliminate metastatic tumors. A major limitation of this promising approach is the rapid loss of ACT T-cell effector function in...

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Bibliografiske detaljer
Main Authors: Zheng, Yiran, Stephan, Matthias, Gai, S. Annie, Abraham, Wuhbet, Shearer, Adrianne, Irvine, Darrell J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046900/
https://ncbi.nlm.nih.gov/pubmed/23770010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.05.037
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