Substrate Deconstruction and the Nonadditivity of Enzyme Recognition

[Image: see text] Predicting substrates for enzymes of unknown function is a major postgenomic challenge. Substrate discovery, like inhibitor discovery, is constrained by our ability to explore chemotypes; it would be expanded by orders of magnitude if reactive sites could be probed with fragments r...

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Autori principali: Barelier, Sarah, Cummings, Jennifer A., Rauwerdink, Alissa M., Hitchcock, Daniel S., Farelli, Jeremiah D., Almo, Steven C., Raushel, Frank M., Allen, Karen N., Shoichet, Brian K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046767/
https://ncbi.nlm.nih.gov/pubmed/24791931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja501354q
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