Substrate Deconstruction and the Nonadditivity of Enzyme Recognition

[Image: see text] Predicting substrates for enzymes of unknown function is a major postgenomic challenge. Substrate discovery, like inhibitor discovery, is constrained by our ability to explore chemotypes; it would be expanded by orders of magnitude if reactive sites could be probed with fragments r...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Barelier, Sarah, Cummings, Jennifer A., Rauwerdink, Alissa M., Hitchcock, Daniel S., Farelli, Jeremiah D., Almo, Steven C., Raushel, Frank M., Allen, Karen N., Shoichet, Brian K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046767/
https://ncbi.nlm.nih.gov/pubmed/24791931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja501354q
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia