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The Assignment of Pterin Deaminase Activity to an Enzyme of Unknown Function Guided by Homology Modeling and Docking

Of the over 22 million protein sequences in the nonredundant TrEMBL database, fewer than 1% have experimentally confirmed functions. Structure-based methods have been used to predict enzyme activities from experimentally determined structures; however, for the vast majority of proteins, no such stru...

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Autors principals: Fan, Hao, Hitchcock, Daniel S., Seidel, Ronald D., Hillerich, Brandan, Lin, Henry, Almo, Steven C., Sali, Andrej, Shoichet, Brian K., Raushel, Frank M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557803/
https://ncbi.nlm.nih.gov/pubmed/23256477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309680b
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