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The Assignment of Pterin Deaminase Activity to an Enzyme of Unknown Function Guided by Homology Modeling and Docking

Of the over 22 million protein sequences in the nonredundant TrEMBL database, fewer than 1% have experimentally confirmed functions. Structure-based methods have been used to predict enzyme activities from experimentally determined structures; however, for the vast majority of proteins, no such stru...

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Détails bibliographiques
Auteurs principaux: Fan, Hao, Hitchcock, Daniel S., Seidel, Ronald D., Hillerich, Brandan, Lin, Henry, Almo, Steven C., Sali, Andrej, Shoichet, Brian K., Raushel, Frank M.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557803/
https://ncbi.nlm.nih.gov/pubmed/23256477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309680b
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