Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily

The rapid advance in genome sequencing presents substantial challenges for protein functional assignment, with half or more of new protein sequences inferred from these genomes having uncertain assignments. The assignment of enzyme function in functionally diverse superfamilies represents a particul...

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Detalhes bibliográficos
Main Authors: Lukk, Tiit, Sakai, Ayano, Kalyanaraman, Chakrapani, Brown, Shoshana D., Imker, Heidi J., Song, Ling, Fedorov, Alexander A., Fedorov, Elena V., Toro, Rafael, Hillerich, Brandan, Seidel, Ronald, Patskovsky, Yury, Vetting, Matthew W., Nair, Satish K., Babbitt, Patricia C., Almo, Steven C., Gerlt, John A., Jacobson, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306705/
https://ncbi.nlm.nih.gov/pubmed/22392983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112081109
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