Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily

The rapid advance in genome sequencing presents substantial challenges for protein functional assignment, with half or more of new protein sequences inferred from these genomes having uncertain assignments. The assignment of enzyme function in functionally diverse superfamilies represents a particul...

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Bibliografiska uppgifter
Huvudupphovsmän: Lukk, Tiit, Sakai, Ayano, Kalyanaraman, Chakrapani, Brown, Shoshana D., Imker, Heidi J., Song, Ling, Fedorov, Alexander A., Fedorov, Elena V., Toro, Rafael, Hillerich, Brandan, Seidel, Ronald, Patskovsky, Yury, Vetting, Matthew W., Nair, Satish K., Babbitt, Patricia C., Almo, Steven C., Gerlt, John A., Jacobson, Matthew P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306705/
https://ncbi.nlm.nih.gov/pubmed/22392983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112081109
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