Evolution of Enzymatic Activities in the Enolase Superfamily: L-Rhamnonate Dehydratase

The L-rhamnonate dehydratase (RhamD) function was assigned to a previously uncharacterized family in the mechanistically diverse enolase superfamily that is encoded by the genome of Escherichia coli K-12. We screened a library of acid sugars to discover that the enzyme displays a promiscuous substra...

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Main Authors: Rakus, John F., Fedorov, Alexander A., Fedorov, Elena V., Glasner, Margaret E., Hubbard, Brian K., Delli, Joseph D., Babbitt, Patricia C., Almo, Steven C., Gerlt, John A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562705/
https://ncbi.nlm.nih.gov/pubmed/18754693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800914r
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