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Rescue of the Orphan Enzyme Isoguanine Deaminase

Cytosine deaminase (CDA) from Escherichia coli was shown to catalyze the deamination of isoguanine (2-oxoadenine) to xanthine. Isoguanine is an oxidation product of adenine in DNA that is mutagenic to the cell. The isoguanine deaminase activity in E. coli was partially purified by ammonium sulfate f...

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Detalhes bibliográficos
Main Authors: Hitchcock, Daniel S., Fedorov, Alexander A., Fedorov, Elena V., Dangott, Lawrence J., Almo, Steven C., Raushel, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138507/
https://ncbi.nlm.nih.gov/pubmed/21604715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200680y
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