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The Three-Dimensional Structure and Catalytic Mechanism of Cytosine Deaminase()
Cytosine deaminase (CDA) from E. coli is a member of the amidohydrolase superfamily. The structure of the zinc-activated enzyme was determined in the presence of phosphonocytosine, a mimic of the tetrahedral reaction intermediate. This compound inhibits the deamination of cytosine with a K(i) of 52...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107989/ https://ncbi.nlm.nih.gov/pubmed/21545144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200483k |
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