Catalytic Mechanism and Three-Dimensional Structure of Adenine Deaminase

Adenine deaminase (ADE) catalyzes the conversion of adenine to hypoxanthine and ammonia. The enzyme isolated from Escherichia coli using standard expression conditions was low for the deamination of adenine (k(cat) = 2.0 s(−1); k(cat)/K(m) = 2.5 × 10(3) M(−1) s(−1)). However, when iron was sequester...

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Bibliographische Detailangaben
Hauptverfasser: Kamat, Siddhesh S., Bagaria, Ashima, Kumaran, Desigan, Holmes-Hampton, Gregory P., Fan, Hao, Sali, Andrej, Sauder, J. Michael, Burley, Stephen K., Lindahl, Paul A., Swaminathan, Subramanyam, Raushel, Frank M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059353/
https://ncbi.nlm.nih.gov/pubmed/21247091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101788n
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