Catalytic Mechanism and Three-Dimensional Structure of Adenine Deaminase

Adenine deaminase (ADE) catalyzes the conversion of adenine to hypoxanthine and ammonia. The enzyme isolated from Escherichia coli using standard expression conditions was low for the deamination of adenine (k(cat) = 2.0 s(−1); k(cat)/K(m) = 2.5 × 10(3) M(−1) s(−1)). However, when iron was sequester...

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Autori principali: Kamat, Siddhesh S., Bagaria, Ashima, Kumaran, Desigan, Holmes-Hampton, Gregory P., Fan, Hao, Sali, Andrej, Sauder, J. Michael, Burley, Stephen K., Lindahl, Paul A., Swaminathan, Subramanyam, Raushel, Frank M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059353/
https://ncbi.nlm.nih.gov/pubmed/21247091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101788n
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