Catalytic Mechanism and Three-Dimensional Structure of Adenine Deaminase

Adenine deaminase (ADE) catalyzes the conversion of adenine to hypoxanthine and ammonia. The enzyme isolated from Escherichia coli using standard expression conditions was low for the deamination of adenine (k(cat) = 2.0 s(−1); k(cat)/K(m) = 2.5 × 10(3) M(−1) s(−1)). However, when iron was sequester...

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Bibliographic Details
Main Authors: Kamat, Siddhesh S., Bagaria, Ashima, Kumaran, Desigan, Holmes-Hampton, Gregory P., Fan, Hao, Sali, Andrej, Sauder, J. Michael, Burley, Stephen K., Lindahl, Paul A., Swaminathan, Subramanyam, Raushel, Frank M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059353/
https://ncbi.nlm.nih.gov/pubmed/21247091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101788n
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