Catalytic Mechanism and Three-Dimensional Structure of Adenine Deaminase

Adenine deaminase (ADE) catalyzes the conversion of adenine to hypoxanthine and ammonia. The enzyme isolated from Escherichia coli using standard expression conditions was low for the deamination of adenine (k(cat) = 2.0 s(−1); k(cat)/K(m) = 2.5 × 10(3) M(−1) s(−1)). However, when iron was sequester...

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Autores principales: Kamat, Siddhesh S., Bagaria, Ashima, Kumaran, Desigan, Holmes-Hampton, Gregory P., Fan, Hao, Sali, Andrej, Sauder, J. Michael, Burley, Stephen K., Lindahl, Paul A., Swaminathan, Subramanyam, Raushel, Frank M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059353/
https://ncbi.nlm.nih.gov/pubmed/21247091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101788n
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