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Structure-based activity prediction for an enzyme of unknown function

With many genomes sequenced, a pressing challenge in biology is predicting the function of the proteins that the genes encode. When proteins are unrelated to others of known activity, bioinformatics inference for function becomes problematic. It would thus be useful to interrogate protein structures...

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Detalhes bibliográficos
Main Authors: Hermann, Johannes C., Marti-Arbona, Ricardo, Fedorov, Alexander A., Fedorov, Elena, Almo, Steven C., Shoichet, Brian K., Raushel, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254328/
https://ncbi.nlm.nih.gov/pubmed/17603473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05981
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