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Covalent Docking Predicts Substrates for Haloalkanoate Dehalogenase Superfamily Phosphatases

[Image: see text] Enzyme function prediction remains an important open problem. Though structure-based modeling, such as metabolite docking, can identify substrates of some enzymes, it is ill-suited to reactions that progress through a covalent intermediate. Here we investigated the ability of coval...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Biochemistry
Main Authors: London, Nir, Farelli, Jeremiah D., Brown, Shoshana D., Liu, Chunliang, Huang, Hua, Korczynska, Magdalena, Al-Obaidi, Nawar F., Babbitt, Patricia C., Almo, Steven C., Allen, Karen N., Shoichet, Brian K.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303301/
https://ncbi.nlm.nih.gov/pubmed/25513739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501140k
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