Covalent Docking Predicts Substrates for Haloalkanoate Dehalogenase Superfamily Phosphatases

[Image: see text] Enzyme function prediction remains an important open problem. Though structure-based modeling, such as metabolite docking, can identify substrates of some enzymes, it is ill-suited to reactions that progress through a covalent intermediate. Here we investigated the ability of coval...

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Bibliographic Details
Published in:Biochemistry
Main Authors: London, Nir, Farelli, Jeremiah D., Brown, Shoshana D., Liu, Chunliang, Huang, Hua, Korczynska, Magdalena, Al-Obaidi, Nawar F., Babbitt, Patricia C., Almo, Steven C., Allen, Karen N., Shoichet, Brian K.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303301/
https://ncbi.nlm.nih.gov/pubmed/25513739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501140k
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