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Enzyme Promiscuity: Engine of Evolutionary Innovation

Catalytic promiscuity and substrate ambiguity are keys to evolvability, which in turn is pivotal to the successful acquisition of novel biological functions. Action on multiple substrates (substrate ambiguity) can be harnessed for performance of functions in the cell that supersede catalysis of a si...

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Detalhes bibliográficos
Main Authors: Pandya, Chetanya, Farelli, Jeremiah D., Dunaway-Mariano, Debra, Allen, Karen N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215207/
https://ncbi.nlm.nih.gov/pubmed/25210039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R114.572990
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