Covalent Conjugation of a Peptide Triazole to HIV-1 gp120 Enables Intramolecular Binding Site Occupancy

[Image: see text] The HIV-1 gp120 glycoprotein is the main viral surface protein responsible for initiation of the entry process and, as such, can be targeted for the development of entry inhibitors. We previously identified a class of broadly active peptide triazole (PT) dual antagonists that inhib...

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Bibliografiske detaljer
Main Authors: Emileh, Ali, Duffy, Caitlin, Holmes, Andrew P., Rosemary Bastian, Arangassery, Aneja, Rachna, Tuzer, Ferit, Rajagopal, Srivats, Li, Huiyuan, Abrams, Cameron F., Chaiken, Irwin M.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045323/
https://ncbi.nlm.nih.gov/pubmed/24801282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500136f
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