Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions

BACKGROUND: We examined the underlying mechanism of action of the peptide triazole thiol, KR13 that has been shown previously to specifically bind gp120, block cell receptor site interactions and potently inhibit HIV-1 infectivity. RESULTS: KR13, the sulfhydryl blocked KR13b and its parent non-sulfh...

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Hauptverfasser: Bastian, Arangassery Rosemary, Contarino, Mark, Bailey, Lauren D, Aneja, Rachna, Moreira, Diogo Rodrigo Magalhaes, Freedman, Kevin, McFadden, Karyn, Duffy, Caitlin, Emileh, Ali, Leslie, George, Jacobson, Jeffrey M, Hoxie, James A, Chaiken, Irwin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878761/
https://ncbi.nlm.nih.gov/pubmed/24330857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-153
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