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Disulfide Sensitivity in the Env Protein Underlies Lytic Inactivation of HIV-1 by Peptide Triazole Thiols

We investigated the mode of action underlying lytic inactivation of HIV-1 virions by peptide triazole thiol (PTT), in particular the relationship between gp120 disulfides and the C-terminal cysteine-SH required for virolysis. Obligate PTT dimer obtained by PTT SH cross-linking and PTTs with serially...

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Publicado en:ACS Chem Biol
Main Authors: Bailey, Lauren D., Sundaram, Ramalingam Venkat Kalyana, Li, Huiyuan, Duffy, Caitlin, Aneja, Rachna, Bastian, Arangassery Rosemary, Holmes, Andrew P., Kamanna, Kantharaju, Rashad, Adel A., Chaiken, Irwin
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836388/
https://ncbi.nlm.nih.gov/pubmed/26458166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00381
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