Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120

We used coordinated mutagenesis, synthetic design, and flexible docking to investigate the structural mechanism of Env gp120 encounter by peptide triazole (PT) inactivators of HIV-1. Prior results demonstrated that the PT class of inhibitors suppresses binding at both CD4 and coreceptor sites on Env...

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Vydáno v:J Med Chem
Hlavní autoři: Aneja, Rachna, Rashad, Adel A., Li, Huiyuan, Sundaram, Ramalingam Venkat Kalyana, Duffy, Caitlin, Bailey, Lauren D., Chaiken, Irwin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497506/
https://ncbi.nlm.nih.gov/pubmed/25860784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00073
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