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Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter
We derived macrocyclic HIV-1 antagonists as a new class of peptidomimetic drug leads. Cyclic peptide triazoles (cPTs) retained the gp120 inhibitory and virus-inactivating signature of parent PTs, arguing that cyclization locked an active conformation. The 6-residue cPT 9 (AAR029b) exhibited sub-micr...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4936186/ https://ncbi.nlm.nih.gov/pubmed/26331669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00935 |
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