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CRISPR/Cas9-Mediated Phage Resistance Is Not Impeded by the DNA Modifications of Phage T4

Bacteria rely on two known DNA-level defenses against their bacteriophage predators: restriction-modification and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated (Cas) systems. Certain phages have evolved countermeasures that are known to block endonucleases. For...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yaung, Stephanie J., Esvelt, Kevin M., Church, George M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041780/
https://ncbi.nlm.nih.gov/pubmed/24886988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098811
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