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Orthogonal Cas9 Proteins for RNA-Guided Gene Regulation and Editing
The Cas9 protein from the Streptococcus pyogenes CRISPR-Cas immune system has been adapted for both RNA-guided genome editing and gene regulation in a variety of organisms, but can mediate only a single activity at a time within any given cell. Here we characterize a set of fully orthogonal Cas9 pro...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3844869/ https://ncbi.nlm.nih.gov/pubmed/24076762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2681 |
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