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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
Prokaryotic type II CRISPR-Cas systems can be adapted to enable targeted genome modifications across a range of eukaryotes.(1–7). Here we engineer this system to enable RNA-guided genome regulation in human cells by tethering transcriptional activation domains either directly to a nuclease-null Cas9...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3818127/ https://ncbi.nlm.nih.gov/pubmed/23907171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2675 |
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