ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor initiating cell state

Glioblastomas (GBM) harbor subpopulations of therapy-resistant tumor initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397-kDa transcriptio...

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Main Authors: Chudnovsky, Yakov, Kim, Dohoon, Zheng, Siyuan, Whyte, Warren A., Bansal, Mukesh, Bray, Mark-Anthony, Gopal, Shuba, Theisen, Matthew A., Bilodeau, Steve, Thiru, Prathapan, Muffat, Julien, Yilmaz, Omer H., Mitalipova, Maya, Woolard, Kevin, Lee, Jeongwu, Nishimura, Riko, Sakata, Nobuo, Fine, Howard A., Carpenter, Anne E., Silver, Serena J., Verhaak, Roel G. W., Califano, Andrea, Young, Richard A., Ligon, Keith L., Mellinghoff, Ingo K., Root, David E., Sabatini, David M., Hahn, William C., Chheda, Milan G.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041390/
https://ncbi.nlm.nih.gov/pubmed/24440720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.032
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