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Re-examining how complexin inhibits neurotransmitter release

Complexins play activating and inhibitory functions in neurotransmitter release. The complexin accessory helix inhibits release and was proposed to insert into SNARE complexes to prevent their full assembly. This model was supported by ‘superclamp’ and ‘poor-clamp’ mutations that enhanced or decreas...

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Hlavní autoři: Trimbuch, Thorsten, Xu, Junjie, Flaherty, David, Tomchick, Diana R, Rizo, Josep, Rosenmund, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040926/
https://ncbi.nlm.nih.gov/pubmed/24842998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02391
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