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Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system

Complexins (Cplxs) are key regulators of synaptic exocytosis, but whether they act as facilitators or inhibitors is currently being disputed controversially. We show that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca(2+)-triggered and spontaneous neurotransmitte...

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Autors principals: Xue, Mingshan, Stradomska, Alicja, Chen, Hongmei, Brose, Nils, Zhang, Weiqi, Rosenmund, Christian, Reim, Kerstin
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409395/
https://ncbi.nlm.nih.gov/pubmed/18505837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803012105
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