Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation

Oncogene-induced senescence (OIS) is an initial barrier to tumor development. Reactive oxygen species (ROS) is critical for oncogenic Ras OIS, but the downstream effectors to mediate ROS signaling are still relatively elusive. Senescent cells develop a senescence-associated secretory phenotype (SASP...

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Autors principals: Wang, Pan, Han, Limin, Shen, Hong, Wang, Pengfeng, Lv, Cuicui, Zhao, Ganye, Niu, Jing, Xue, Lixiang, Wang, Qiming Jane, Tong, Tanjun, Chen, Jun
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040603/
https://ncbi.nlm.nih.gov/pubmed/24828530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310972111
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