Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation

Oncogene-induced senescence (OIS) is an initial barrier to tumor development. Reactive oxygen species (ROS) is critical for oncogenic Ras OIS, but the downstream effectors to mediate ROS signaling are still relatively elusive. Senescent cells develop a senescence-associated secretory phenotype (SASP...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Pan, Han, Limin, Shen, Hong, Wang, Pengfeng, Lv, Cuicui, Zhao, Ganye, Niu, Jing, Xue, Lixiang, Wang, Qiming Jane, Tong, Tanjun, Chen, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040603/
https://ncbi.nlm.nih.gov/pubmed/24828530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310972111
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