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Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation
Oncogene-induced senescence (OIS) is an initial barrier to tumor development. Reactive oxygen species (ROS) is critical for oncogenic Ras OIS, but the downstream effectors to mediate ROS signaling are still relatively elusive. Senescent cells develop a senescence-associated secretory phenotype (SASP...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040603/ https://ncbi.nlm.nih.gov/pubmed/24828530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310972111 |
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