Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation

Oncogene-induced senescence (OIS) is an initial barrier to tumor development. Reactive oxygen species (ROS) is critical for oncogenic Ras OIS, but the downstream effectors to mediate ROS signaling are still relatively elusive. Senescent cells develop a senescence-associated secretory phenotype (SASP...

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Detalhes bibliográficos
Main Authors: Wang, Pan, Han, Limin, Shen, Hong, Wang, Pengfeng, Lv, Cuicui, Zhao, Ganye, Niu, Jing, Xue, Lixiang, Wang, Qiming Jane, Tong, Tanjun, Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040603/
https://ncbi.nlm.nih.gov/pubmed/24828530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310972111
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