Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation

Oncogene-induced senescence (OIS) is an initial barrier to tumor development. Reactive oxygen species (ROS) is critical for oncogenic Ras OIS, but the downstream effectors to mediate ROS signaling are still relatively elusive. Senescent cells develop a senescence-associated secretory phenotype (SASP...

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Bibliografiska uppgifter
Huvudupphovsmän: Wang, Pan, Han, Limin, Shen, Hong, Wang, Pengfeng, Lv, Cuicui, Zhao, Ganye, Niu, Jing, Xue, Lixiang, Wang, Qiming Jane, Tong, Tanjun, Chen, Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040603/
https://ncbi.nlm.nih.gov/pubmed/24828530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310972111
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