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Sp1 Is Essential for p16(INK4a) Expression in Human Diploid Fibroblasts during Senescence
BACKGROUND: p16 (INK4a) tumor suppressor protein has been widely proposed to mediate entrance of the cells into the senescent stage. Promoter of p16 (INK4a) gene contains at least five putative GC boxes, named GC-I to V, respectively. Our previous data showed that a potential Sp1 binding site, withi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1764714/ https://ncbi.nlm.nih.gov/pubmed/17225865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000164 |
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