Sp1 Is Essential for p16(INK4a) Expression in Human Diploid Fibroblasts during Senescence

BACKGROUND: p16 (INK4a) tumor suppressor protein has been widely proposed to mediate entrance of the cells into the senescent stage. Promoter of p16 (INK4a) gene contains at least five putative GC boxes, named GC-I to V, respectively. Our previous data showed that a potential Sp1 binding site, withi...

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Bibliographic Details
Main Authors: Wu, Junfeng, Xue, Lixiang, Weng, Mo, Sun, Ying, Zhang, Zongyu, Wang, Wengong, Tong, Tanjun
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1764714/
https://ncbi.nlm.nih.gov/pubmed/17225865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000164
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