SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

Sir2, a NAD-dependent deacetylase, modulates lifespan in yeasts, worms and flies. The SIRT1, mammalian homologue of Sir2, regulates signaling for favoring survival in stress. But whether SIRT1 has the function to influence cell viability and senescence under non-stressed conditions in human diploid...

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Autori principali: Huang, Jing, Gan, Qini, Han, Limin, Li, Jian, Zhang, Hai, Sun, Ying, Zhang, Zongyu, Tong, Tanjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2249701/
https://ncbi.nlm.nih.gov/pubmed/18320031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001710
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