SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation

Sirtuin6 (SIRT6) has been implicated as a key factor in aging and aging-related diseases. However, the role of SIRT6 in cellular senescence has not been fully understood. Here, we show that SIRT6 repressed the expression of p27(Kip1) (p27) in cellular senescence. The expression of SIRT6 was reduced...

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Vydáno v:Aging (Albany NY)
Hlavní autoři: Zhao, Ganye, Wang, Hui, Xu, Chenzhong, Wang, Pan, Chen, Jun, Wang, Pengfeng, Sun, Zhaomeng, Su, Yuanyuan, Wang, Zhao, Han, Limin, Tong, Tanjun
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115890/
https://ncbi.nlm.nih.gov/pubmed/27794562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101038
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