SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation

Sirtuin6 (SIRT6) has been implicated as a key factor in aging and aging-related diseases. However, the role of SIRT6 in cellular senescence has not been fully understood. Here, we show that SIRT6 repressed the expression of p27(Kip1) (p27) in cellular senescence. The expression of SIRT6 was reduced...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Aging (Albany NY)
Egile Nagusiak: Zhao, Ganye, Wang, Hui, Xu, Chenzhong, Wang, Pan, Chen, Jun, Wang, Pengfeng, Sun, Zhaomeng, Su, Yuanyuan, Wang, Zhao, Han, Limin, Tong, Tanjun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2016
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115890/
https://ncbi.nlm.nih.gov/pubmed/27794562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101038
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