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New Insights into Rotavirus Entry Machinery: Stabilization of Rotavirus Spike Conformation Is Independent of Trypsin Cleavage

The infectivity of rotavirus, the main causative agent of childhood diarrhea, is dependent on activation of the extracellular viral particles by trypsin-like proteases in the host intestinal lumen. This step entails proteolytic cleavage of the VP4 spike protein into its mature products, VP8* and VP5...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rodríguez, Javier M., Chichón, Francisco J., Martín-Forero, Esther, González-Camacho, Fernando, Carrascosa, José L., Castón, José R., Luque, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038622/
https://ncbi.nlm.nih.gov/pubmed/24873828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004157
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