pH-Induced Conformational Change of the Rotavirus VP4 Spike: Implications for Cell Entry and Antibody Neutralization

The rotavirus spike protein, VP4, is a major determinant of infectivity and neutralization. Previously, we have shown that trypsin-enhanced infectivity of rotavirus involves a transformation of the VP4 spike from a flexible to a rigid bilobed structure. Here we show that at elevated pH the spike und...

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Detalhes bibliográficos
Main Authors: Pesavento, Joseph B., Crawford, Sue E., Roberts, Ed, Estes, Mary K., Prasad, B. V. Venkataram
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143764/
https://ncbi.nlm.nih.gov/pubmed/15956598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.13.8572-8580.2005
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