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Mutations in the rotavirus spike protein VP4 reduce trypsin sensitivity but not viral spread
Infectious entry of the nonenveloped rotavirus virion requires proteolysis of the spike protein VP4 to mediate conformational changes associated with membrane penetration. We sequenced and characterized an isolate that was cultured in the absence of trypsin and found that it is more resistant to pro...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for General Microbiology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3709623/ https://ncbi.nlm.nih.gov/pubmed/23426355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.050674-0 |
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