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Mutations in the rotavirus spike protein VP4 reduce trypsin sensitivity but not viral spread

Infectious entry of the nonenveloped rotavirus virion requires proteolysis of the spike protein VP4 to mediate conformational changes associated with membrane penetration. We sequenced and characterized an isolate that was cultured in the absence of trypsin and found that it is more resistant to pro...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Trask, Shane D., Wetzel, J. Denise, Dermody,, Terence S., Patton, John T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for General Microbiology 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709623/
https://ncbi.nlm.nih.gov/pubmed/23426355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.050674-0
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