Targeted disruption of Hotair leads to homeotic transformation and gene de-repression

Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformatio...

Fuld beskrivelse

Na minha lista:

Bibliografiske detaljer
Main Authors:	Li, Lingjie, Liu, Bo, Wapinski, Orly L., Tsai, Miao-Chih, Qu, Kun, Zhang, Jiajing, Carlson, Jeff C., Lin, Meihong, Fang, Fengqin, Gupta, Rajnish A., Helms, Jill A., Chang, Howard Y.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2013
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4038295/ https://ncbi.nlm.nih.gov/pubmed/24075995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.003
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!

Targeted disruption of Hotair leads to homeotic transformation and gene de-repression

Lignende værker