Targeted disruption of Hotair leads to homeotic transformation and gene de-repression

Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformatio...

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Bibliografski detalji
Glavni autori: Li, Lingjie, Liu, Bo, Wapinski, Orly L., Tsai, Miao-Chih, Qu, Kun, Zhang, Jiajing, Carlson, Jeff C., Lin, Meihong, Fang, Fengqin, Gupta, Rajnish A., Helms, Jill A., Chang, Howard Y.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038295/
https://ncbi.nlm.nih.gov/pubmed/24075995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.003
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