Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Large intervening noncoding RNAs (lincRNAs) are pervasively transcribed in the genome1, 2, 3 yet their potential involvement in human disease is not well understood4,5. Recent studies of dosage compensation, imprinting, and homeotic gene expression suggest that individual lincRNAs can function as th...

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Main Authors: Gupta, Rajnish A., Shah, Nilay, Wang, Kevin C., Kim, Jeewon, Horlings, Hugo M., Wong, David J., Tsai, Miao-Chih, Hung, Tiffany, Argani, Pedram, Rinn, John L., Wang, Yulei, Brzoska, Pius, Kong, Benjamin, Li, Rui, West, Robert B., van de Vijver, Marc J., Sukumar, Saraswati, Chang, Howard Y.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049919/
https://ncbi.nlm.nih.gov/pubmed/20393566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08975
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