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The Role of One-Electron Reduction of Lipid Hydroperoxides in Causing DNA Damage
The in vivo metabolism of plasma lipids generates lipid hydroperoxides that, upon one-electron reduction, gives rise to a wide spectrum of genotoxic unsaturated aldehydes and epoxides. These metabolites react with cellular DNA to form a variety of pre-mutagenic DNA lesions. The mechanisms of action...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4036807/ https://ncbi.nlm.nih.gov/pubmed/19746460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.200900500 |
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