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Methylation of 2’-Deoxyguanosine by a Free Radical Mechanism

The mechanistic aspects of the methylation of guanine in DNA initiated by methyl radicals that are derived from the metabolic oxidation of some chemical carcinogens remain poorly understood. In this work we investigated the kinetics and the formation of methylated guanine products by two methods: (i...

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Detalhes bibliográficos
Main Authors: Crean, Conor, Geacintov, Nicholas E., Shafirovich, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754879/
https://ncbi.nlm.nih.gov/pubmed/19719172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp903554n
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