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Generation of Guanine – Amino Acid Cross-Links by a Free Radical Combination Mechanism

A direct method has been developed for the in vitro synthesis of stable DNA – protein cross-links (DPC’s) between guanine and amino acids (lysine, arginine). This method employs the combination of guanine neutral radicals, G(-H)(•), and side-chain C-centered amino acid radicals. The latter were gene...

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Autors principals: Uvaydov, Yuriy, Geacintov, Nicholas E., Shafirovich, Vladimir
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068030/
https://ncbi.nlm.nih.gov/pubmed/24810398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cp00675e
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