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Generation of Guanine – Thymidine Cross-links in DNA by Peroxynitrite/Carbon Dioxide

Nitrosoperoxycarbonate derived from the combination of carbon dioxide and peroxynitrite, is an important chemical mediator of inflammation. In aqueous solutions, it rapidly decomposes to the reactive species CO(3)(•−) and (•)NO(2) radicals that are known to initiate the selective oxidation and nitra...

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Detalhes bibliográficos
Main Authors: Yun, Byeong Hwa, Geacintov, Nicholas E., Shafirovich, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138886/
https://ncbi.nlm.nih.gov/pubmed/21513308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200139c
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