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Generation of Guanine -Thymine Crosslinks in Human Cells by One-Electron Oxidation Mechanisms

The one-electron oxidation of cellular DNA in cultured human HeLa cells initiated by intense nanosecond 266 nm laser pulse irradiation produces cross-links between guanine and thymine bases (G*-T*), characterized by a covalent bond between C8 guanine (G*) and N3 thymine (T*) atoms. The DNA lesions w...

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Main Authors: Madugundu, Guru S., Wagner, Richard, Cadet, Jean, Kropachev, Konstantin, Yun, Byeong Hwa, Geacintov, Nicholas E., Shafirovich, Vladimir
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812307/
https://ncbi.nlm.nih.gov/pubmed/23734842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400158g
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