The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

Aggregation of the amyloid-β peptide (Aβ) into toxic oligomers and amyloid fibrils is linked to the development of Alzheimer’s disease (AD). Mutations of the BRICHOS chaperone domain are associated with amyloid disease and recent in vitro data show that BRICHOS efficiently delays Aβ42 oligomerizatio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hermansson, Erik, Schultz, Sebastian, Crowther, Damian, Linse, Sara, Winblad, Bengt, Westermark, Gunilla, Johansson, Jan, Presto, Jenny
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Limited 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036473/
https://ncbi.nlm.nih.gov/pubmed/24682783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.014787
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