The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

Aggregation of the amyloid-β peptide (Aβ) into toxic oligomers and amyloid fibrils is linked to the development of Alzheimer’s disease (AD). Mutations of the BRICHOS chaperone domain are associated with amyloid disease and recent in vitro data show that BRICHOS efficiently delays Aβ42 oligomerizatio...

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Bibliographic Details
Main Authors: Hermansson, Erik, Schultz, Sebastian, Crowther, Damian, Linse, Sara, Winblad, Bengt, Westermark, Gunilla, Johansson, Jan, Presto, Jenny
Format: Artigo
Language:Inglês
Published: The Company of Biologists Limited 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036473/
https://ncbi.nlm.nih.gov/pubmed/24682783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.014787
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