High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C

BRICHOS domains are encoded in > 30 human genes, which are associated with cancer, neurodegeneration, and interstitial lung disease (ILD). The BRICHOS domain from lung surfactant protein C proprotein (proSP-C) is required for membrane insertion of SP-C and has anti-amyloid activity in vitro. Here...

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Bibliografische gegevens
Hoofdauteurs: Willander, Hanna, Askarieh, Glareh, Landreh, Michael, Westermark, Per, Nordling, Kerstin, Keränen, Henrik, Hermansson, Erik, Hamvas, Aaron, Nogee, Lawrence M., Bergman, Tomas, Saenz, Alejandra, Casals, Cristina, Åqvist, Johan, Jörnvall, Hans, Berglund, Helena, Presto, Jenny, Knight, Stefan D., Johansson, Jan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289314/
https://ncbi.nlm.nih.gov/pubmed/22308375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114740109
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