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BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

Aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils in islets of Langerhans is associated with type 2 diabetes, and formation of toxic IAPP species is believed to contribute to the loss of insulin-producing beta cells. The BRICHOS domain of integral membrane protein 2B (Bri2), a tra...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Oskarsson, Marie E., Hermansson, Erik, Wang, Ye, Welsh, Nils, Presto, Jenny, Johansson, Jan, Westermark, Gunilla T.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866560/
https://ncbi.nlm.nih.gov/pubmed/29507232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715951115
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