BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

Aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils in islets of Langerhans is associated with type 2 diabetes, and formation of toxic IAPP species is believed to contribute to the loss of insulin-producing beta cells. The BRICHOS domain of integral membrane protein 2B (Bri2), a tra...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Oskarsson, Marie E., Hermansson, Erik, Wang, Ye, Welsh, Nils, Presto, Jenny, Johansson, Jan, Westermark, Gunilla T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866560/
https://ncbi.nlm.nih.gov/pubmed/29507232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715951115
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