BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

Aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils in islets of Langerhans is associated with type 2 diabetes, and formation of toxic IAPP species is believed to contribute to the loss of insulin-producing beta cells. The BRICHOS domain of integral membrane protein 2B (Bri2), a tra...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Oskarsson, Marie E., Hermansson, Erik, Wang, Ye, Welsh, Nils, Presto, Jenny, Johansson, Jan, Westermark, Gunilla T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2018
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866560/
https://ncbi.nlm.nih.gov/pubmed/29507232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715951115
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